Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells

LLL12 exhibits high specificity for inhibiting STAT3 phosphorylation and dimerization, and inducing apoptosis to constitutively activated STAT3 cancer cells without cytotoxicity to normal cells with dormant STAT3. However, clinical deployment of LLL12 in cancer treatment is hindered by its low bioav...

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Detalles Bibliográficos
Autores principales: Xu, Jinshun, Yuan, Shuai, Tian, Jilai, Martin, Kyle A., Song, Jinhua, Li, Chenglong, Wang, Zhigang, Lin, Jiayuh, Si, Ting, Xu, Ronald X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359616/
https://www.ncbi.nlm.nih.gov/pubmed/28322306
http://dx.doi.org/10.1038/srep44908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359616/
https://www.ncbi.nlm.nih.gov/pubmed/28322306
http://dx.doi.org/10.1038/srep44908

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