A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase

Valosin-containing protein (VCP/p97) ATPase (a.k.a. Cdc48) is a key member of the ER-associated protein degradation (ERAD) pathway. ERAD and VCP/p97 have been implicated in a multitude of human diseases, such as neurodegenerative diseases and cancer. Inhibition of VCP/p97 induces proteotoxic ER stre...

Descripción completa

Detalles Bibliográficos
Autores principales: Segura-Cabrera, Aldo, Tripathi, Reshmi, Zhang, Xiaoyi, Gui, Lin, Chou, Tsui-Fen, Komurov, Kakajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359624/
https://www.ncbi.nlm.nih.gov/pubmed/28322292
http://dx.doi.org/10.1038/srep44912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359624/
https://www.ncbi.nlm.nih.gov/pubmed/28322292
http://dx.doi.org/10.1038/srep44912

Ejemplares similares