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A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase

Valosin-containing protein (VCP/p97) ATPase (a.k.a. Cdc48) is a key member of the ER-associated protein degradation (ERAD) pathway. ERAD and VCP/p97 have been implicated in a multitude of human diseases, such as neurodegenerative diseases and cancer. Inhibition of VCP/p97 induces proteotoxic ER stre...

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Detalles Bibliográficos
Autores principales:	Segura-Cabrera, Aldo, Tripathi, Reshmi, Zhang, Xiaoyi, Gui, Lin, Chou, Tsui-Fen, Komurov, Kakajan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359624/ https://www.ncbi.nlm.nih.gov/pubmed/28322292 http://dx.doi.org/10.1038/srep44912

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