Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle

Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that...

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Detalles Bibliográficos
Autores principales: Ho, Shu-Chuan, Wu, Sheng-Ming, Feng, Po-Hao, Liu, Wen-Te, Chen, Kuan-Yuan, Chuang, Hsiao-Chi, Chan, Yao-Fei, Kuo, Lu-Wei, Lee, Kang-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359717/
https://www.ncbi.nlm.nih.gov/pubmed/28322300
http://dx.doi.org/10.1038/srep44930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359717/
https://www.ncbi.nlm.nih.gov/pubmed/28322300
http://dx.doi.org/10.1038/srep44930

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