Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

Neuropathic pain is a major unmet medical need, with only 30% to 35% of patients responding to the current standard of care. The discovery and development of novel therapeutics to address this unmet need have been hampered by poor target engagement, the selectivity of novel molecules, and limited ac...

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Detalles Bibliográficos
Autores principales: Webster, Carl I., Hatcher, Jon, Burrell, Matthew, Thom, George, Thornton, Peter, Gurrell, Ian, Chessell, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359788/
https://www.ncbi.nlm.nih.gov/pubmed/28009628
http://dx.doi.org/10.1097/j.pain.0000000000000810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359788/
https://www.ncbi.nlm.nih.gov/pubmed/28009628
http://dx.doi.org/10.1097/j.pain.0000000000000810

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