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Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy
BACKGROUND: Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. Generating potent CAR T cells is of increasing importance in the field. Studies have demonstrated the importance of the Akt pathw...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359873/ https://www.ncbi.nlm.nih.gov/pubmed/28331616 http://dx.doi.org/10.1186/s40425-017-0227-4 |