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β-Hairpin mimics containing a piperidine–pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species
Alzheimer's disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid β peptides, with Aβ(1–42) being the most aggregative and neurotoxic one. We report herein the synthesis and conformational analysis of Aβ(1–42)-amyloid related β-hairpin peptidomimetics,...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359901/ https://www.ncbi.nlm.nih.gov/pubmed/28451272 http://dx.doi.org/10.1039/c6sc03176e |