Cargando…

Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2

BACKGROUND: Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are widely used as herb medicine in China. In the present study, we investigated the an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Dong, Jin, Junzhe, Yu, Hao, Zhao, Zheming, Ma, Dongyan, Zhang, Chundong, Jiang, Honglei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359903/ https://www.ncbi.nlm.nih.gov/pubmed/28320429 http://dx.doi.org/10.1186/s13046-017-0514-4

Ejemplares similares

By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma
por: Yao, Junliang, et al.
Publicado: (2018)

Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma
por: Jiang, Honglei, et al.
Publicado: (2017)

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells
por: Li, Man, et al.
Publicado: (2017)

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

Butein Inhibited In Vitro Hexokinase-2-Mediated Tumor Glycolysis in Hepatocellular Carcinoma by Blocking Epidermal Growth Factor Receptor (EGFR)
por: Liao, Weirong, et al.
Publicado: (2018)

Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
por: Yu, Qiang, et al.
Publicado: (2022)

Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis
por: Gandham, Srujan Kumar, et al.
Publicado: (2015)

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
por: Dai, Weiqi, et al.
Publicado: (2015)

miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma
por: Sun, Zhanwei, et al.
Publicado: (2017)

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma
por: Guo, Wenzheng, et al.
Publicado: (2020)

Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma
por: Yoo, Jeong-Ju, et al.
Publicado: (2019)

Potassium ions promote hexokinase-II dependent glycolysis
por: Bischof, Helmut, et al.
Publicado: (2021)

NEDD9 sustains hexokinase expression to promote glycolysis
por: Deneka, Alexander Y., et al.
Publicado: (2022)

Potassium ions promote hexokinase-II dependent glycolysis
por: Bischof, Helmut, et al.
Publicado: (2021)

MicroRNA-202 suppresses glycolysis of pancreatic cancer by targeting hexokinase 2
por: Wang, Shuang-Jia, et al.
Publicado: (2021)

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis
por: Liu, Wenbin, et al.
Publicado: (2019)

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
por: Caillot, M., et al.
Publicado: (2020)

miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension
por: Luo, Li, et al.
Publicado: (2020)

Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2
por: Ban, Dujing, et al.
Publicado: (2019)

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria
por: Lauterwasser, Joachim, et al.
Publicado: (2021)

How Do Hexokinases Inhibit Receptor-Mediated Apoptosis?
por: Schoeniger, Axel, et al.
Publicado: (2022)

Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression
por: Wu, Zhenqian, et al.
Publicado: (2020)

Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities
por: Meng, Ya-Ming, et al.
Publicado: (2021)

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
por: Li, Wei, et al.
Publicado: (2017)

Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis
por: Yuan, Jian, et al.
Publicado: (2020)

Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway
por: Wu, Hongyan, et al.
Publicado: (2019)

A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma
por: Feng, Yilu, et al.
Publicado: (2020)

Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2
por: He, Haiyan, et al.
Publicado: (2023)

Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells
por: Liu, Yulin, et al.
Publicado: (2017)

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
por: Wolf, Amparo, et al.
Publicado: (2011)

Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
por: Li, Jingjing, et al.
Publicado: (2017)

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
por: Gershon, Timothy R, et al.
Publicado: (2013)

Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells
por: Kim, Dong Jun, et al.
Publicado: (2019)

Sinomenine Inhibits Non-Small Cell Lung Cancer via Downregulation of Hexokinases II-Mediated Aerobic Glycolysis
por: Liu, Wenbin, et al.
Publicado: (2020)

Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells()
por: Mukherjee, Abir, et al.
Publicado: (2015)

Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis
por: Chen, Xin, et al.
Publicado: (2021)

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma
por: Wei, L, et al.
Publicado: (2013)

Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis
por: Chen, Ya, et al.
Publicado: (2022)

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis
por: Shao, Meng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_veu6u95mlsauo27hfbe9urmlm6