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Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironmen...

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Detalles Bibliográficos
Autores principales: Scarfò, Irene, Maus, Marcela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359946/
https://www.ncbi.nlm.nih.gov/pubmed/28331617
http://dx.doi.org/10.1186/s40425-017-0230-9