Palladium(0)-catalyzed asymmetric C(sp(3))–H arylation using a chiral binol-derived phosphate and an achiral ligand

The first efficient palladium(0)-catalyzed enantioselective C(sp(3))–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels...

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Detalles Bibliográficos
Autores principales: Yang, Lei, Melot, Romain, Neuburger, Markus, Baudoin, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360168/
https://www.ncbi.nlm.nih.gov/pubmed/28451275
http://dx.doi.org/10.1039/c6sc04006c
Descripción
Sumario:The first efficient palladium(0)-catalyzed enantioselective C(sp(3))–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

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