Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360235/
https://www.ncbi.nlm.nih.gov/pubmed/28323820
http://dx.doi.org/10.1371/journal.pbio.2001882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360235/
https://www.ncbi.nlm.nih.gov/pubmed/28323820
http://dx.doi.org/10.1371/journal.pbio.2001882

Ejemplares similares