Cargando…

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating the levels of plasma low-density lipoprotein cholesterol (LDL-C). Here, we demonstrate that the compound PF-06446846 inhibits translation of PCSK9 by inducing the ribosome to stall around codon 34, mediated by the s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360235/ https://www.ncbi.nlm.nih.gov/pubmed/28323820 http://dx.doi.org/10.1371/journal.pbio.2001882

Ejemplares similares

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
por: Lintner, Nathanael G., et al.
Publicado: (2018)

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
por: Li, Wenfei, et al.
Publicado: (2019)

The Ribosome Restrains Molten Globule Formation in Stalled Nascent Flavodoxin
por: Houwman, Joseline A., et al.
Publicado: (2016)

Nascent MSKIK peptide cancels ribosomal stalling by arrest peptides in Escherichia coli
por: Ojima-Kato, Teruyo, et al.
Publicado: (2023)

Computational analysis of nascent peptides that induce ribosome stalling and their proteomic distribution in Saccharomyces cerevisiae
por: Sabi, Renana, et al.
Publicado: (2017)

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon
por: von der Malsburg, Karina, et al.
Publicado: (2015)

Polysomes identified by live imaging of nascent peptides are stalled in hippocampal and cortical neurites
por: Langille, Jesse J., et al.
Publicado: (2019)

Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
por: Verma, Rati, et al.
Publicado: (2018)

Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain
por: Koch, Miriam, et al.
Publicado: (2017)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2020)

The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks
por: Zhang, Junqiu, et al.
Publicado: (2022)

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells
por: Lazarchuk, Pavlo, et al.
Publicado: (2023)

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
por: Yonashiro, Ryo, et al.
Publicado: (2016)

Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
por: Garzón, Javier, et al.
Publicado: (2019)

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
por: Balasubramanian, Sandhya, et al.
Publicado: (2022)

Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction
por: Takamatsu, Seidai, et al.
Publicado: (2020)

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA
por: Ormsby, Angelique R., et al.
Publicado: (2020)

Cellular response to small molecules that selectively stall protein synthesis by the ribosome
por: Liaud, Nadège, et al.
Publicado: (2019)

A stalled fork stalls recombination
por: Tuma, Rabiya S.
Publicado: (2005)

Nascent chain dynamics and ribosome interactions within folded ribosome–nascent chain complexes observed by NMR spectroscopy
por: Burridge, Charles, et al.
Publicado: (2021)

Ribosome Stalling of N-Linked Glycoproteins in Cell-Free Extracts
por: Chung, Sean S., et al.
Publicado: (2022)

STALLing for signaling
por: Powell, Kendall
Publicado: (2007)

Ubiquitination of stalled ribosome triggers ribosome-associated quality control
por: Matsuo, Yoshitaka, et al.
Publicado: (2017)

Human NMD ensues independently of stable ribosome stalling
por: Karousis, Evangelos D., et al.
Publicado: (2020)

The deubiquitylase USP9X controls ribosomal stalling
por: Clancy, Anne, et al.
Publicado: (2021)

In vitro Analysis of Stalled Ribosomes Using Puromycin Incorporation
por: Scarpitti, MaKenzie R., et al.
Publicado: (2023)

Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis
por: Prattes, Michael, et al.
Publicado: (2019)

Stalling secretase assembly
por: Williams, Ruth
Publicado: (2007)

The Stall Grid Contest
por: Keshava, Shyamkumar Nidugala, et al.
Publicado: (2015)

Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site
por: Starosta, Agata L., et al.
Publicado: (2014)

The fail-safe system to rescue the stalled ribosomes in Escherichia coli
por: Abo, Tatsuhiko, et al.
Publicado: (2014)

Mechanisms of ribosome stalling by SecM at multiple elongation steps
por: Zhang, Jun, et al.
Publicado: (2015)

Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes
por: Weaver, Jeremy, et al.
Publicado: (2019)

Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
por: Barth, Valdir C., et al.
Publicado: (2019)

CAT tails drive degradation of stalled polypeptides on and off the ribosome
por: Sitron, Cole S., et al.
Publicado: (2019)

Correction: The deubiquitylase USP9X controls ribosomal stalling
por: Clancy, Anne, et al.
Publicado: (2021)

Structure of Gcn1 bound to stalled and colliding 80S ribosomes
por: Pochopien, Agnieszka A., et al.
Publicado: (2021)

Translational buffering by ribosome stalling in upstream open reading frames
por: Bottorff, Ty A., et al.
Publicado: (2022)

Identification of factors that prevent ribosome stalling during early elongation
por: Hye-Rim, Hong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nlt6pj9u1qfiqeh094kkruv7h3