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Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas
The Hedgehog (Hh) pathway is critical for cell differentiation, tissue polarity, and stem cell maintenance during embryonic development, but is silent in adult tissues under normal conditions. However, aberrant Hh signaling activation has been implicated in the development and promotion of certain t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360396/ https://www.ncbi.nlm.nih.gov/pubmed/28352196 http://dx.doi.org/10.2147/OTT.S130910 |