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The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease
Polyglutamine disorders are chronic, progressive neurodegenerative diseases caused by expansion of a glutamine tract in widely expressed genes. Despite excellent models of disease, a well-documented clinical history and progression, and established genetic causes, there are no FDA approved, disease...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360718/ https://www.ncbi.nlm.nih.gov/pubmed/28381987 http://dx.doi.org/10.3389/fnmol.2017.00078 |