KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

The mechanistic target of rapamycin complex 1 kinase (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy(1–3). Amino acids are a key input, and act through the Rag GTPases to promote th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wolfson, Rachel L., Chantranupong, Lynne, Wyant, Gregory A., Gu, Xin, Orozco, Jose M., Shen, Kuang, Condon, Kendall J., Petri, Sabrina, Kedir, Jibril, Scaria, Sonia M., Abu-Remaileh, Monther, Frankel, Wayne N., Sabatini, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360989/
https://www.ncbi.nlm.nih.gov/pubmed/28199306
http://dx.doi.org/10.1038/nature21423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360989/
https://www.ncbi.nlm.nih.gov/pubmed/28199306
http://dx.doi.org/10.1038/nature21423

Ejemplares similares