Probing Medin Monomer Structure and its Amyloid Nucleation Using (13)C-Direct Detection NMR in Combination with Structural Bioinformatics

Aortic medial amyloid is the most prevalent amyloid found to date, but remarkably little is known about it. It is characterised by aberrant deposition of a 5.4 kDa protein called medin within the medial layer of large arteries. Here we employ a combined approach of ab initio protein modelling and (1...

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Detalles Bibliográficos
Autores principales: Davies, Hannah A., Rigden, Daniel J., Phelan, Marie M., Madine, Jillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361114/
https://www.ncbi.nlm.nih.gov/pubmed/28327552
http://dx.doi.org/10.1038/srep45224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361114/
https://www.ncbi.nlm.nih.gov/pubmed/28327552
http://dx.doi.org/10.1038/srep45224

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