Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons

Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopaminergic neurons via conditional deletion of the Ndufs4 gene, a subunit of the mitochondrial...

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Detalles Bibliográficos
Autores principales: Choi, Won-Seok, Kim, Hyung-Wook, Tronche, François, Palmiter, Richard D., Storm, Daniel R., Xia, Zhengui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361188/
https://www.ncbi.nlm.nih.gov/pubmed/28327638
http://dx.doi.org/10.1038/srep44989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361188/
https://www.ncbi.nlm.nih.gov/pubmed/28327638
http://dx.doi.org/10.1038/srep44989

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