Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25

Ubiquitin-specific protease (USP) 25, belonging to the USP family of deubiquitinases, harbors two tandem ubiquitin-interacting motifs (UIMs), a ~20-amino-acid α-helical stretch that binds to ubiquitin. However, the role of the UIMs in USP25 remains unclear. Here we show that the tandem UIM region bi...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Kohei, Uo, Kazune, Tanaka, Toshiaki, Komada, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361193/
https://www.ncbi.nlm.nih.gov/pubmed/28327663
http://dx.doi.org/10.1038/srep45037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361193/
https://www.ncbi.nlm.nih.gov/pubmed/28327663
http://dx.doi.org/10.1038/srep45037

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