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Global identification and analysis of isozyme-specific possible substrates crosslinked by transglutaminases using substrate peptides in mouse liver fibrosis

The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evi...

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Detalles Bibliográficos
Autores principales: Tatsukawa, Hideki, Tani, Yuji, Otsu, Risa, Nakagawa, Haruka, Hitomi, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361200/
https://www.ncbi.nlm.nih.gov/pubmed/28327670
http://dx.doi.org/10.1038/srep45049