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Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin

Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms. The data showed that (1) BAA treatment induced phosphorylation of CREB (rather than NF-κB) an...

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Detalles Bibliográficos
Autores principales: Li, Teng-Fei, Wu, Hai-Yun, Wang, Yi-Rui, Li, Xin-Yan, Wang, Yong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361206/
https://www.ncbi.nlm.nih.gov/pubmed/28327597
http://dx.doi.org/10.1038/srep45056