Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises...

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Detalles Bibliográficos
Autores principales: Miroshnikova, Yekaterina A., Mouw, Janna K., Barnes, J. Matthew, Pickup, Michael W., Lakins, Johnathan N., Kim, Youngmi, Lobo, Khadjia, Persson, Anders I., Reis, Gerald F., McKnight, Tracy R., Holland, Eric C., Phillips, Joanna J., Weaver, Valerie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://www.ncbi.nlm.nih.gov/pubmed/27820599
http://dx.doi.org/10.1038/ncb3429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://www.ncbi.nlm.nih.gov/pubmed/27820599
http://dx.doi.org/10.1038/ncb3429

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