Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes

PURPOSE: EFEMP1 (fibulin-3) is mutated in Malattia Leventinese/Doyne's honeycomb retinal dystrophy (ML/DHRD), an inherited macular dystrophy similar to AMD. Both ML/DHRD and AMD are characterized by the presence of sub-RPE deposits. Efemp1 knockout mice do not develop sub-RPE deposits. This stu...

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Detalles Bibliográficos
Autores principales: Stanton, James B., Marmorstein, Alan D., Zhang, Youwen, Marmorstein, Lihua Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361459/
https://www.ncbi.nlm.nih.gov/pubmed/28264101
http://dx.doi.org/10.1167/iovs.16-20955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361459/
https://www.ncbi.nlm.nih.gov/pubmed/28264101
http://dx.doi.org/10.1167/iovs.16-20955

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