Cargando…

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes

PURPOSE: EFEMP1 (fibulin-3) is mutated in Malattia Leventinese/Doyne's honeycomb retinal dystrophy (ML/DHRD), an inherited macular dystrophy similar to AMD. Both ML/DHRD and AMD are characterized by the presence of sub-RPE deposits. Efemp1 knockout mice do not develop sub-RPE deposits. This stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stanton, James B., Marmorstein, Alan D., Zhang, Youwen, Marmorstein, Lihua Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361459/ https://www.ncbi.nlm.nih.gov/pubmed/28264101 http://dx.doi.org/10.1167/iovs.16-20955

Ejemplares similares

Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane
por: Zayas-Santiago, Astrid, et al.
Publicado: (2017)

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7
por: Zhang, Youwen, et al.
Publicado: (2017)

Risuteganib Protects against Hydroquinone–induced Injury in Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2020)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
por: Sreekumar, Parameswaran G., et al.
Publicado: (2016)

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae
por: Nakanishi, Masataka, et al.
Publicado: (2016)

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2017)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

Medium Depth Influences O(2) Availability and Metabolism in Human RPE Cultures
por: Hass, Daniel T., et al.
Publicado: (2023)

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material
por: Zhang, Qitao, et al.
Publicado: (2019)

Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction
por: Lin, Bin, et al.
Publicado: (2020)

DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency
por: Swinkels, Daniëlle, et al.
Publicado: (2023)

Complement C5 is not critical for the formation of sub-RPE deposits in Efemp1 mutant mice
por: Garland, Donita L., et al.
Publicado: (2021)

Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin
por: Galloway, Chad A., et al.
Publicado: (2018)

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells
por: Vu, Khiem T., et al.
Publicado: (2017)

Light-Induced Smooth Endoplasmic Reticulum Rearrangement in a Unique Interlaced Compartmental Pattern in Macaca mulatta RPE
por: Altera, Annalisa, et al.
Publicado: (2021)

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN
por: Hamuro, Junji, et al.
Publicado: (2023)

Loss of Axin2 Causes Ocular Defects During Mouse Eye Development
por: Alldredge, Ashley, et al.
Publicado: (2016)

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease
por: Derbyshire, Mark L., et al.
Publicado: (2023)

Subretinal Glial Membranes in Eyes With Geographic Atrophy
por: Edwards, Malia M., et al.
Publicado: (2017)

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
por: Pilgrim, Matthew G., et al.
Publicado: (2017)

Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells
por: Neal, Samantha E., et al.
Publicado: (2020)

Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration
por: McLeod, D. Scott, et al.
Publicado: (2016)

Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice
por: Fu, Zhongjie, et al.
Publicado: (2017)

N-Acetylcysteine Amide Protects Against Oxidative Stress–Induced Microparticle Release From Human Retinal Pigment Epithelial Cells
por: Carver, Kyle A., et al.
Publicado: (2016)

Autofluorescent Organelles Within the Retinal Pigment Epithelium in Human Donor Eyes With and Without Age-Related Macular Degeneration
por: Bermond, Katharina, et al.
Publicado: (2022)

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies
por: Bertolesi, Gabriel E., et al.
Publicado: (2023)

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model
por: Wu, You-Ren, et al.
Publicado: (2021)

Fluorescence Lifetimes and Spectra of RPE and Sub-RPE Deposits in Histology of Control and AMD Eyes
por: Schultz, Rowena, et al.
Publicado: (2020)

Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination
por: Simmons, Aaron B., et al.
Publicado: (2016)

Multiple Invagination Patterns and Synaptic Efficacy in Primate and Mouse Rod Synaptic Terminals
por: Tsukamoto, Yoshihiko, et al.
Publicado: (2022)

The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity
por: Hackett, Sean F., et al.
Publicado: (2017)

Helical Fasciculation of Bipolar and Horizontal Cell Neurites for Wiring With Photoreceptors in Macaque and Mouse Retinas
por: Tsukamoto, Yoshihiko, et al.
Publicado: (2021)

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection
por: Zhao, Jing, et al.
Publicado: (2022)

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy
por: Shi, Shuizhen, et al.
Publicado: (2023)

Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina
por: Park, Ko Uoon, et al.
Publicado: (2017)

Vulnerability of Dopaminergic Amacrine Cells to Chronic Ischemia in a Mouse Model of Oxygen-Induced Retinopathy
por: Spix, Nathan J., et al.
Publicado: (2016)

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency
por: Nagar, Saumya, et al.
Publicado: (2017)

The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina
por: Groman-Lupa, Sergio, et al.
Publicado: (2017)

Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium
por: Goyal, Varunika, et al.
Publicado: (2020)

Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy
por: Warwick, Alexander M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r91dtks6qnh6jk7scdip4p411r