Addressing Adherence Using Genotype-Specific PBPK Modeling—Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels

Introduction: Tamoxifen is one of the most common treatment opportunities for hormonal positive breast cancer. Despite its good tolerability, patients demonstrate decreasing adherence over years impacting on therapeutic success. PBPK modeling was applied to demonstrate the impact of drug holidays on...

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Detalles Bibliográficos
Autores principales: Dickschen, Kristin J. R., Willmann, Stefan, Hempel, Georg, Block, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361661/
https://www.ncbi.nlm.nih.gov/pubmed/28382001
http://dx.doi.org/10.3389/fphar.2017.00067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361661/
https://www.ncbi.nlm.nih.gov/pubmed/28382001
http://dx.doi.org/10.3389/fphar.2017.00067

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