A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

BACKGROUND: Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow. This multicenter, phase...

Descripción completa

Detalles Bibliográficos
Autores principales: Vadhan-Raj, Saroj, Abonour, Rafat, Goldman, Jonathan W., Smith, David A., Slapak, Christopher A., Ilaria, Robert L., Tiu, Ramon V., Wang, Xuejing, Callies, Sophie, Cox, Joanne, Tuttle, Jay L., Lau, Yiu-Keung, Roeland, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361694/
https://www.ncbi.nlm.nih.gov/pubmed/28327200
http://dx.doi.org/10.1186/s13045-017-0427-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361694/
https://www.ncbi.nlm.nih.gov/pubmed/28327200
http://dx.doi.org/10.1186/s13045-017-0427-x

Ejemplares similares