CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear qua...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Jean-Ju, Miki, Kiyoshi, Kim, Doory, Shim, Sang-Hee, Shi, Huanan F, Hwang, Jae Yeon, Cai, Xinjiang, Iseri, Yusuf, Zhuang, Xiaowei, Clapham, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362262/
https://www.ncbi.nlm.nih.gov/pubmed/28226241
http://dx.doi.org/10.7554/eLife.23082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362262/
https://www.ncbi.nlm.nih.gov/pubmed/28226241
http://dx.doi.org/10.7554/eLife.23082

Ejemplares similares