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CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear qua...

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Detalles Bibliográficos
Autores principales:	Chung, Jean-Ju, Miki, Kiyoshi, Kim, Doory, Shim, Sang-Hee, Shi, Huanan F, Hwang, Jae Yeon, Cai, Xinjiang, Iseri, Yusuf, Zhuang, Xiaowei, Clapham, David E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362262/ https://www.ncbi.nlm.nih.gov/pubmed/28226241 http://dx.doi.org/10.7554/eLife.23082

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