Cargando…

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC

Over a half million new cases of Head and Neck Squamous Cell Carcinoma (HNSCC) are diagnosed annually worldwide, however, 5 year overall survival is only 50% for HNSCC patients. Recently, high throughput technologies have accelerated the genome-wide characterization of HNSCC. However, comprehensive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaykalova, Daria A., Zizkova, Veronika, Guo, Theresa, Tiscareno, Ilse, Wei, Yingying, Vatapalli, Rajita, Hennessey, Patrick T., Ahn, Julie, Danilova, Ludmila, Khan, Zubair, Bishop, Justin A., Silvio Gutkind, J., Koch, Wayne M., Westra, William H., Fertig, Elana J., Ochs, Michael F., Califano, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362490/ https://www.ncbi.nlm.nih.gov/pubmed/28146432 http://dx.doi.org/10.18632/oncotarget.14856

Ejemplares similares

Preferential Activation of the Hedgehog Pathway by Epigenetic Modulations in HPV Negative HNSCC Identified with Meta-Pathway Analysis
por: Fertig, Elana J., et al.
Publicado: (2013)

Dose-Dependent Activation of Putative Oncogene SBSN by BORIS
por: Gaykalova, Daria, et al.
Publicado: (2012)

Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients
por: Gaykalova, Daria A., et al.
Publicado: (2015)

Expression Microarray Analysis Reveals Alternative Splicing of LAMA3 and DST Genes in Head and Neck Squamous Cell Carcinoma
por: Li, Ryan, et al.
Publicado: (2014)

DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma
por: Finegersh, Andrey, et al.
Publicado: (2017)

Hybrid Modeling of Cell Signaling and Transcriptional Reprogramming and Its Application in C. elegans Development
por: Fertig, Elana J., et al.
Publicado: (2011)

Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer
por: Flam, Emily L., et al.
Publicado: (2019)

Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination
por: Stansfield, John C., et al.
Publicado: (2016)

Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines
por: Kagohara, Luciane T., et al.
Publicado: (2020)

Correction: Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines
por: Kagohara, Luciane T., et al.
Publicado: (2020)

Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma
por: Gaykalova, Daria A., et al.
Publicado: (2014)

Correction: Novel Insight into Mutational Landscape of Head and Neck Squamous Cell Carcinoma
por: Gaykalova, Daria A., et al.
Publicado: (2020)

Assessing the Potential Risks of Digital Therapeutics (DTX): The DTX Risk Assessment Canvas
por: Denecke, Kerstin, et al.
Publicado: (2023)

Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance
por: Stein-O’Brien, Genevieve, et al.
Publicado: (2018)

Epigenetic regulation of gene expression in cancer: techniques, resources and analysis
por: Kagohara, Luciane T, et al.
Publicado: (2017)

Extracellular Vesicles Released by Tumor Endothelial Cells Spread Immunosuppressive and Transforming Signals Through Various Recipient Cells
por: Lopatina, Tatiana, et al.
Publicado: (2020)

Comparison of Promoter Hypermethylation Pattern in Salivary Rinses Collected with and without an Exfoliating Brush from Patients with HNSCC
por: Sun, Wenyue, et al.
Publicado: (2012)

Organoids Increase the Predictive Value of in vitro Cancer Chemoprevention Studies for in vivo Outcome
por: Njoroge, Rose N., et al.
Publicado: (2019)

Matrix factorization and transfer learning uncover regulatory biology across multiple single-cell ATAC-seq data sets
por: Erbe, Rossin, et al.
Publicado: (2020)

In Vitro Evaluation of NLS-DTX Activity in Triple-Negative Breast Cancer
por: Paiva, Karen L. R., et al.
Publicado: (2022)

Towards Social Media as DTx in Psychiatry? Current opportunities and pitfalls
por: Orsolini, L.
Publicado: (2023)

Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer
por: Guerrero-Preston, Rafael, et al.
Publicado: (2014)

Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX
por: Ferreiro, Sara F., et al.
Publicado: (2015)

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC
por: Zhang, Kaihua, et al.
Publicado: (2014)

Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors
por: Davis-Marcisak, Emily F., et al.
Publicado: (2021)

Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC
por: Saddawi-Konefka, Robert, et al.
Publicado: (2022)

Biosynthetic Studies on Water-Soluble Derivative 5c (DTX5c)
por: Vilches, Tamara S., et al.
Publicado: (2012)

The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer
por: Scalia, Pierluigi, et al.
Publicado: (2023)

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
por: Ren, Shuling, et al.
Publicado: (2020)

Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma
por: Ding, Xin‐Yu, et al.
Publicado: (2020)

AGA: Interactive pipeline for reproducible gene expression and DNA methylation data analyses
por: Considine, Michael, et al.
Publicado: (2015)

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
por: Jafarnejad, Mohammad, et al.
Publicado: (2019)

Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing
por: Sakai, Akihiro, et al.
Publicado: (2020)

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
por: Gupta, Parul, et al.
Publicado: (2018)

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development
por: Wang, Shanshan, et al.
Publicado: (2020)

Promoter Methylation in Head and Neck Squamous Cell Carcinoma Cell Lines Is Significantly Different than Methylation in Primary Tumors and Xenografts
por: Hennessey, Patrick T., et al.
Publicado: (2011)

Integrative Discovery of Epigenetically Derepressed Cancer Testis Antigens in NSCLC
por: Glazer, Chad A., et al.
Publicado: (2009)

A Mentee’s Baby Registry: Supporting New Academic Parents in 2020
por: Fertig, Elana J.
Publicado: (2020)

Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis
por: Yoo, Seung Soo, et al.
Publicado: (2020)

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase
por: Zhou, Zhifen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kbkqoub4ov1ade6385epund8ga