Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-i...

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Detalles Bibliográficos
Autores principales: Salpini, Romina, Surdo, Matteo, Warner, Nadia, Cortese, Maria Francesca, Colledge, Danny, Soppe, Sally, Bellocchi, Maria Concetta, Armenia, Daniele, Carioti, Luca, Continenza, Fabio, Carlo, Domenico Di, Saccomandi, Patrizia, Mirabelli, Carmen, Pollicita, Michela, Longo, Roberta, Romano, Sara, Cappiello, Giuseppina, Spanò, Alberto, Trimoulet, Pascale, Fleury, Herve, Vecchiet, Jacopo, Iapadre, Nerio, Barlattani, Angelo, Bertoli, Ada, Mari, Terenzio, Pasquazzi, Caterina, Missale, Gabriele, Sarrecchia, Cesare, Orecchini, Elisa, Michienzi, Alessandro, Andreoni, Massimo, Francioso, Simona, Angelico, Mario, Verheyen, Jens, Ceccherini-Silberstein, Francesca, Locarnini, Stephen, Perno, Carlo Federico, Svicher, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362517/
https://www.ncbi.nlm.nih.gov/pubmed/28152517
http://dx.doi.org/10.18632/oncotarget.14944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362517/
https://www.ncbi.nlm.nih.gov/pubmed/28152517
http://dx.doi.org/10.18632/oncotarget.14944

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