DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A

[Image: see text] PR104A is an experimental DNA-alkylating hypoxia-activated prodrug that can also be activated in an oxygen-independent manner by the two-electron aldo-keto reductase 1C3. Nitroreduction leads to the formation of cytotoxic hydroxylamine (PR104H) and amine (PR104M) metabolites, which...

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Detalles Bibliográficos
Autores principales: Stornetta, Alessia, Villalta, Peter W., Gossner, Frederike, Wilson, William R., Balbo, Silvia, Sturla, Shana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362746/
https://www.ncbi.nlm.nih.gov/pubmed/28140568
http://dx.doi.org/10.1021/acs.chemrestox.6b00412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362746/
https://www.ncbi.nlm.nih.gov/pubmed/28140568
http://dx.doi.org/10.1021/acs.chemrestox.6b00412

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