Akt targeting as a strategy to boost chemotherapy efficacy in non-small cell lung cancer through metabolism suppression

Metabolic reprogramming is a hallmark of cancer development, mediated by genetic and epigenetic alterations that may be pharmacologically targeted. Among oncogenes, the kinase Akt is commonly overexpressed in tumors and favors glycolysis, providing a rationale for using Akt inhibitors. Here, we addr...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Grand, Marion, Berges, Raphael, Pasquier, Eddy, Montero, Marie-Pierre, Borge, Laurence, Carrier, Alice, Vasseur, Sophie, Bourgarel, Veronique, Buric, Duje, André, Nicolas, Braguer, Diane, Carré, Manon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362809/
https://www.ncbi.nlm.nih.gov/pubmed/28332584
http://dx.doi.org/10.1038/srep45136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362809/
https://www.ncbi.nlm.nih.gov/pubmed/28332584
http://dx.doi.org/10.1038/srep45136

Ejemplares similares