Calmodulin is responsible for Ca(2+)-dependent regulation of TRPA1 Channels

TRPA1 is a Ca(2+)-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca(2+), with low Ca(2+) potentiating and high Ca(2+) inactivating TRPA1. However, it remains unknown how Ca(2+) exerts such contrasting effects. Her...

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Detalles Bibliográficos
Autores principales: Hasan, Raquibul, Leeson-Payne, Alasdair T. S., Jaggar, Jonathan H., Zhang, Xuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362816/
https://www.ncbi.nlm.nih.gov/pubmed/28332600
http://dx.doi.org/10.1038/srep45098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362816/
https://www.ncbi.nlm.nih.gov/pubmed/28332600
http://dx.doi.org/10.1038/srep45098

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