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Calmodulin is responsible for Ca(2+)-dependent regulation of TRPA1 Channels
TRPA1 is a Ca(2+)-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca(2+), with low Ca(2+) potentiating and high Ca(2+) inactivating TRPA1. However, it remains unknown how Ca(2+) exerts such contrasting effects. Her...
Autores principales: | Hasan, Raquibul, Leeson-Payne, Alasdair T. S., Jaggar, Jonathan H., Zhang, Xuming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362816/ https://www.ncbi.nlm.nih.gov/pubmed/28332600 http://dx.doi.org/10.1038/srep45098 |
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