Cargando…

LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway

Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by activation of different transcription factors collectively known as EMT-TFs. Different cellular cues and cell signalling networks activate EMT at transcriptional and po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cuevas, Eva P., Eraso, Pilar, Mazón, María J., Santos, Vanesa, Moreno-Bueno, Gema, Cano, Amparo, Portillo, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362953/ https://www.ncbi.nlm.nih.gov/pubmed/28332555 http://dx.doi.org/10.1038/srep44988

Ejemplares similares

LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition
por: Cuevas, Eva P., et al.
Publicado: (2014)

LOXL2 in Cancer: A Two-Decade Perspective
por: Cano, Amparo, et al.
Publicado: (2023)

New Functions of Intracellular LOXL2: Modulation of RNA-Binding Proteins
por: Eraso, Pilar, et al.
Publicado: (2023)

E47 and Id1 Interplay in Epithelial-Mesenchymal Transition
por: Cubillo, Eva, et al.
Publicado: (2013)

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity
por: Qiao, Dianhua, et al.
Publicado: (2023)

Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival
por: Vázquez-Naharro, Alberto, et al.
Publicado: (2022)

Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development
por: Santamaría, Patricia G., et al.
Publicado: (2022)

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
por: Moreno-Bueno, Gema, et al.
Publicado: (2011)

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives
por: Díaz-López, Antonio, et al.
Publicado: (2014)

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
por: Ribeiro, Carla M. P., et al.
Publicado: (2017)

IRE1α Promotes Zika Virus Infection via XBP1
por: Kolpikova, Elena P., et al.
Publicado: (2020)

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
por: Huang, Huai-Wei, et al.
Publicado: (2017)

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
por: Grandjean, Julia M.D., et al.
Publicado: (2020)

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology
por: Aghaei, Mahmoud, et al.
Publicado: (2021)

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
por: Madhavan, Aparajita, et al.
Publicado: (2022)

Ebola Virus Activates IRE1α-Dependent XBP1u Splicing
por: Rohde, Cornelius, et al.
Publicado: (2022)

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
por: Tam, Arvin B., et al.
Publicado: (2014)

Characterization of Two Second-Site Mutations Preventing Wild Type Protein Aggregation Caused by a Dominant Negative PMA1 Mutant
por: Eraso, Pilar, et al.
Publicado: (2013)

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
por: Hassler, Justin R., et al.
Publicado: (2015)

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response
por: Jiang, Dadi, et al.
Publicado: (2016)

IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2018)

IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing’s sarcoma
por: Tanabe, Yu, et al.
Publicado: (2018)

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
por: Cairrão, Fátima, et al.
Publicado: (2022)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity
por: Richardson, Claire E., et al.
Publicado: (2011)

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
por: Lin, Jianhuang, et al.
Publicado: (2021)

Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation
por: Tohmonda, Takahide, et al.
Publicado: (2012)

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
por: Sheng, Xia, et al.
Publicado: (2019)

Correction: IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2019)

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
por: Song, Minkyung, et al.
Publicado: (2018)

Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response
por: Bechill, John, et al.
Publicado: (2006)

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation
por: Yang, Shuai, et al.
Publicado: (2022)

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway
por: Shishova, Anna, et al.
Publicado: (2022)

Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling
por: Shen, Wei-Bin, et al.
Publicado: (2023)

The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli
por: English, Bevin C., et al.
Publicado: (2022)

IRE1/XBP1 and endoplasmic reticulum signaling — from basic to translational research for cardiovascular disease
por: Fu, Fangyi, et al.
Publicado: (2022)

The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection
por: Oda, Jessica M., et al.
Publicado: (2023)

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
por: Chalmers, Fiona, et al.
Publicado: (2017)

Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response
por: Qiao, Dianhua, et al.
Publicado: (2021)

IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes
por: Asada, Rie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tp8hhluef099vtj9tg34tgc615