Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis

In response to oxidative stress, nuclear factor (erythroid-derived 2)-like2 (Nrf2) induces expression of cytoprotective genes. The Nrf2 pathway is controlled by microRNAs and Kelch-like ECH-associated protein1 (Keap1). Nrf2 is stabilized when Keap1 is degraded through the autophagy pathway in a p62-...

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Detalles Bibliográficos
Autores principales: Wasik, Urszula, Milkiewicz, Małgorzata, Kempinska-Podhorodecka, Agnieszka, Milkiewicz, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363061/
https://www.ncbi.nlm.nih.gov/pubmed/28333129
http://dx.doi.org/10.1038/srep44769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363061/
https://www.ncbi.nlm.nih.gov/pubmed/28333129
http://dx.doi.org/10.1038/srep44769

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