The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). G...

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Detalles Bibliográficos
Autores principales: Park, Kyung-Won, Eun Kim, Gyoung, Morales, Rodrigo, Moda, Fabio, Moreno-Gonzalez, Ines, Concha-Marambio, Luis, Lee, Amy S., Hetz, Claudio, Soto, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://www.ncbi.nlm.nih.gov/pubmed/28333162
http://dx.doi.org/10.1038/srep44723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://www.ncbi.nlm.nih.gov/pubmed/28333162
http://dx.doi.org/10.1038/srep44723

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