Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

In T cells with transgenic high-avidity T cell receptors (TCRs), endogenous and transferred TCR chains compete for surface expression and may pair inappropriately, potentially causing autoimmunity. To knock out endogenous TCR expression, we assembled 12 transcription activator-like effector nuclease...

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Detalles Bibliográficos
Autores principales: Knipping, Friederike, Osborn, Mark J., Petri, Karl, Tolar, Jakub, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred, Gabriel, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363317/
https://www.ncbi.nlm.nih.gov/pubmed/28345006
http://dx.doi.org/10.1016/j.omtm.2017.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363317/
https://www.ncbi.nlm.nih.gov/pubmed/28345006
http://dx.doi.org/10.1016/j.omtm.2017.01.005

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