Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes

Duchenne muscular dystrophy (DMD) is a lethal, X-linked, muscle-wasting disorder caused by mutations in the large, 2.4-Mb dystrophin gene. The majority of DMD-causing mutations are sporadic, multi-exon, frameshifting deletions, with the potential for variable immunological tolerance to the dystrophi...

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Detalles Bibliográficos
Autores principales: VanBelzen, D. Jake, Malik, Alock S., Henthorn, Paula S., Kornegay, Joe N., Stedman, Hansell H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363321/
https://www.ncbi.nlm.nih.gov/pubmed/28344992
http://dx.doi.org/10.1016/j.omtm.2016.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363321/
https://www.ncbi.nlm.nih.gov/pubmed/28344992
http://dx.doi.org/10.1016/j.omtm.2016.12.001

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