GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

Integration site profiling and clonality analysis of viral vector distribution in gene therapy is a key factor to monitor the fate of gene-corrected cells, assess the risk of malignant transformation, and establish vector biosafety. We developed the Genome Integration Site Analysis Pipeline (GENE-IS...

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Detalles Bibliográficos
Autores principales: Afzal, Saira, Wilkening, Stefan, von Kalle, Christof, Schmidt, Manfred, Fronza, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363413/
https://www.ncbi.nlm.nih.gov/pubmed/28325279
http://dx.doi.org/10.1016/j.omtn.2016.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363413/
https://www.ncbi.nlm.nih.gov/pubmed/28325279
http://dx.doi.org/10.1016/j.omtn.2016.12.001

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