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Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
A main challenge in realizing the full potential of nucleic acid therapeutics is efficient delivery of them into targeted tissues and cells. N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety benefiting from its high affinity with asialoglycoprotein receptor (ASGPR). By conjugati...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society of Gene & Cell Therapy
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363494/ https://www.ncbi.nlm.nih.gov/pubmed/28325278 http://dx.doi.org/10.1016/j.omtn.2016.12.003 |