Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina

The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) has been included in the transgene cassette of adeno-associated virus (AAV) in several gene therapy clinical trials, including those for inherited retinal diseases. However, the extent to which WPRE increases transgene expre...

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Detalles Bibliográficos
Autores principales: Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., McClements, Michelle E., MacLaren, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363497/
https://www.ncbi.nlm.nih.gov/pubmed/28325286
http://dx.doi.org/10.1016/j.omtn.2016.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363497/
https://www.ncbi.nlm.nih.gov/pubmed/28325286
http://dx.doi.org/10.1016/j.omtn.2016.12.006

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