The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation

Death Receptor 5 (DR5) is a promising target for cancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, the therapeutic usefulness of DR5 agonists is currently limited by the frequent resistance of malignant tumours to its activation. The identification of molecu...

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Detalles Bibliográficos
Autores principales: El Zawily, Amr M., Toosi, Behzad M., Freywald, Tanya, Indukuri, Vijaya V., Vizeacoumar, Franco J., Leary, Scot C., Freywald, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363627/
https://www.ncbi.nlm.nih.gov/pubmed/27788485
http://dx.doi.org/10.18632/oncotarget.12838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363627/
https://www.ncbi.nlm.nih.gov/pubmed/27788485
http://dx.doi.org/10.18632/oncotarget.12838

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