miR-135b-5p inhibits LPS-induced TNFα production via silencing AMPK phosphatase Ppm1e

AMPK activation in monocytes could suppress lipopolysaccharide (LPS)-induced tissue-damaging TNFa production. We are set to provoke AMPK activation via microRNA (“miRNA”) downregulating its phosphatase Ppm1e. In human U937 and THP-1 monocytes, forced expression of microRNA-135b-5p (“miR-135b-5p”) do...

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Detalles Bibliográficos
Autores principales: Li, Ping, Fan, Jian-bo, Gao, Yanxia, Zhang, Ming, Zhang, Li, Yang, Ning, Zhao, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363637/
https://www.ncbi.nlm.nih.gov/pubmed/27793001
http://dx.doi.org/10.18632/oncotarget.12866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363637/
https://www.ncbi.nlm.nih.gov/pubmed/27793001
http://dx.doi.org/10.18632/oncotarget.12866

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