Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability

M2-type pyruvate kinase (PKM2) contributes to the Warburg effect. However, it remains unknown as to whether PKM2 has an inhibitory effect on mitochondrial function. We report in this work that PKM2 overexpression inhibits the expression of Drp1 and results in the mitochondrial fusion. The ATP produc...

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Detalles Bibliográficos
Autores principales: Wu, Haili, Yang, Peng, Hu, Wanglai, Wang, Yingying, Lu, Yangxu, Zhang, Lichao, Fan, Yongsheng, Xiao, Hong, Li, Zhuoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363644/
https://www.ncbi.nlm.nih.gov/pubmed/27801666
http://dx.doi.org/10.18632/oncotarget.12942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363644/
https://www.ncbi.nlm.nih.gov/pubmed/27801666
http://dx.doi.org/10.18632/oncotarget.12942

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