CRISPR/Cas9-Mediated Genome Editing Corrects Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy

Muscle stem cells (MuSCs) hold great therapeutic potential for muscle genetic disorders, such as Duchenne muscular dystrophy (DMD). The CRISP/Cas9-based genome editing is a promising technology for correcting genetic alterations in mutant genes. In this study, we used fibrin-gel culture system to se...

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Detalles Bibliográficos
Autores principales: Zhu, Pei, Wu, Furen, Mosenson, Jeffrey, Zhang, Hongmei, He, Tong-Chuan, Wu, Wen-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363682/
https://www.ncbi.nlm.nih.gov/pubmed/28624206
http://dx.doi.org/10.1016/j.omtn.2017.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363682/
https://www.ncbi.nlm.nih.gov/pubmed/28624206
http://dx.doi.org/10.1016/j.omtn.2017.02.007

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