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Non-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation
Conformationally-constrained molecules that selectively recognise the surfaces of proteins have the potential to direct the path of protein folding. Such molecules are of therapeutic interest because the misfolding of proteins, especially that which results in fibrillation and aggregation, is strong...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363787/ https://www.ncbi.nlm.nih.gov/pubmed/28451100 http://dx.doi.org/10.1039/c6sc00756b |