Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccine

The live attenuated vaccine (LAV) SIVmac239Δnef (SIVΔnef) confers the best protection among all the vaccine modalities tested in rhesus macaque model of HIV-1 infection. This vaccine has a unique feature of time-dependent protection: macaques are not protected at 3–5 weeks post vaccination (WPV), wh...

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Detalles Bibliográficos
Autores principales: Lu, Wuxun, Wan, Yanmin, Ma, Fangrui, Johnson, R. Paul, Li, Qingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363825/
https://www.ncbi.nlm.nih.gov/pubmed/28333940
http://dx.doi.org/10.1371/journal.pone.0173929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363825/
https://www.ncbi.nlm.nih.gov/pubmed/28333940
http://dx.doi.org/10.1371/journal.pone.0173929

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