Mechanisms of glycosylase induced genomic instability

Human alkyladenine DNA glycosylase (AAG) initiates base excision repair (BER) to guard against mutations by excising alkylated and deaminated purines. Counterintuitively, increased expression of AAG has been implicated in increased rates of spontaneous mutation in microsatellite repeats. This micros...

Descripción completa

Detalles Bibliográficos
Autores principales: Eyler, Daniel E., Burnham, Kylie A., Wilson, Thomas E., O’Brien, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363859/
https://www.ncbi.nlm.nih.gov/pubmed/28333944
http://dx.doi.org/10.1371/journal.pone.0174041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363859/
https://www.ncbi.nlm.nih.gov/pubmed/28333944
http://dx.doi.org/10.1371/journal.pone.0174041

Ejemplares similares