Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP

The aim of our study was to evaluate possible synergistic cytotoxic effects of the combination treatment with the BH3-mimetic ABT-263 and the PARP inhibitor BMN 673 in high-grade serous ovarian cancer (HGSOC) cells using clinically achievable concentrations of each drug. In vitro cytotoxic effects o...

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Detalles Bibliográficos
Autores principales: Yokoyama, Takuhei, Kohn, Elise C., Brill, Ethan, Lee, Jung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363883/
https://www.ncbi.nlm.nih.gov/pubmed/28350129
http://dx.doi.org/10.3892/ijo.2017.3914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363883/
https://www.ncbi.nlm.nih.gov/pubmed/28350129
http://dx.doi.org/10.3892/ijo.2017.3914

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