CC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related human mortalities. Over-activation of mammalian target of rapamycin (mTOR) is important for HCC tumorigenesis and progression. The current study assessed the potential anti-HCC activity by a novel mTOR kinase inhibitor, CC-223. We d...

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Detalles Bibliográficos
Autores principales: Xie, Zichen, Wang, Jiqin, Liu, Mei, Chen, Deshan, Qiu, Chao, Sun, Keyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363890/
https://www.ncbi.nlm.nih.gov/pubmed/28334043
http://dx.doi.org/10.1371/journal.pone.0173252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363890/
https://www.ncbi.nlm.nih.gov/pubmed/28334043
http://dx.doi.org/10.1371/journal.pone.0173252

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